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Besides the NIH, Van Andel Research Institute, and the Michael J. Fox Foundation, what are other institutions, foundations, organizations, etc. tha…
Does anyone have data that would link the U.S. Affordable Care Act to cost savings for molecular diagnostic tools? If so, could you plea…
Video of the Day
Mayo Clinic E.R. Dr. David Claypool says bee stings can be very dangerous for people who have allergic reactions.
Calendar of Events
Molecular Science in the News
(For more information on the below articles, a subscription to the newspaper (and journal) may be required)
Thursday July 2, 2015
- Study offers clue to link between swine flu shot, narcolepsy: "One vaccine used in Europe during the 2009 swine flu pandemic was linked to rare cases of a baffling side effect - the sleep disorder narcolepsy. Now new research offers a clue to what happened (Science Translational Medicine)…." (Lauran Neergaard, Associated Press)
- Study: Bariatric surgery, lifestyle changes can control Type 2 diabetes: "Bariatric surgery and lifestyle changes may be a key method of controlling Type 2 diabetes over the long haul, according to a UPMC study (JAMA Surgery) published today. While researchers previously demonstrated that the surgery can help improve diabetes, the new study is important because it shows the positive effects lasting…." (Joe Smydo, Pittsburgh Post-Gazette)
- Liberia investigating animal link after Ebola re-emerges: "Liberia confirmed a third Ebola case on Thursday, nearly two months after it was declared Ebola free, and officials said they were investigating whether the disease had managed to lurk in animals before resurfacing. Dr Moses Massaquoi, case management team leader for Liberia's Ebola task force, said the three villagers who had tested positive for the disease had shared a meal of dog meat, which is commonly eaten in Liberia…." (Alphonso Toweh and James Harding Giahyue, Reuters)
- Implanted drug improves tolerance of sunlight in rare condition: "A skin-darkening drug can help protect against serious pain in people with a rare inherited condition that makes them flee sunlight like movie vampires, according to tests in Europe and the U.S (New England Journal of Medicine)…." (Gene Emery, Reuters)
- U.S. campaign highlights stress of fireworks on combat veterans: "Every Independence Day for the past eight years, Shawn Gourley and her family have left their Indiana home for remote campgrounds to escape the fireworks that trigger her veteran husband's wartime memories. Gourley's husband Justin, who served in the U.S. Navy from 2000 to 2004, is one of about 500,000 Iraq and Afghanistan war veterans with post-traumatic stress disorder, which can be worsened by the cracks and thunder of celebratory fireworks…." (Laila Kearney, Reuters)
- Device helps doctors personalize chemotherapy for patients: "A new microarray can test combinations of chemotherapy drugs on a small number of cancer stem cells, allowing doctors to tailor treatment for individual patients faster than such testing generally takes. Currently, doctors determine the best course of treatment by trying combinations of drugs directly on patients (PNAS)…." (Stephen Feller, United Press International)
- FDA to consider warning labels, child-proof bottle for e-liquid: "The Food and Drug Administration announced it plans to consider exposure warnings and child-proof packaging for liquid nicotine and nicotine-containing e-liquids. Calls to poison control centers have increased from an average of 1 per month in 2010 to more than 200 per month…." (Stephen Feller, United Press International)
- Low testosterone linked to higher rates of depression: "More than half of men with low levels of testosterone have depression or depressive symptoms, a rate much higher than among the general population, researchers said in a new study (Journal of Sexual Medicine)…." (Stephen Feller, United Press International)
Wednesday July 1, 2015
- Drug and device firms paid $6.5B to care providers: "From research dollars to free lunches and junkets, drug and medical device companies paid doctors and leading hospitals nearly $6.5 billion last year, according to government data posted Tuesday. The latest update to the Open Payments database is part of an ongoing effort to highlight potential conflicts of interest in medicine…." (Ricardo Alonso-Zaldivar, Associated Press)
- O Say Can You Breathe? Fireworks Pollute Air, Study Says: "July Fourth fireworks fill the skies across the nation with more than sparkling bursts of color. They spew pollution, too. A study (Atmospheric Environment) of 315 locations around the country…." (Malcom Ritter, Associated Press)
- Scientists See Neurons Change as Memories Form: "Learning can be traced back to individual neurons in the brain, according to a new study (Neuron). “What we wanted to do was see if we could actually create a new association — a memory — and see if we would be able to see actual change in the neurons…." (Sindya N. Bhanoo, New York Times)
- Overuse of nursing home antibiotics may put all residents at risk: "Some nursing home facilities prescribe antibiotics more often than others, which is tied to increased health risks, even for residents who don’t receive the medications, according to a new study (JAMA Internal Medicine). About two-thirds of nursing home residents receive antibiotic treatment of some kind each year…." (Kathryn Doyle, Reuters)
- Minor changes turned Black Death germ from mild to murderous: "The bacterium Yersinia pestis has inflicted almost unimaginable misery upon humankind over the centuries, killing an estimated 200 million or more people and triggering horrific plagues in the 6th and 14th centuries. But this germ was not always particularly dangerous. Scientists said on Tuesday minor genetic changes that it underwent many centuries ago (Nature Communications)…." (Will Dunham, Reuters)
- Half of heart disease deaths due to preventable factors: "In the U.S., preventable risk factors still account for 50 percent of deaths from cardiovascular disease among adults age 45 to 79, according to a new analysis (Annals of Internal Medicine)…." (Kathryn Doyle, Reuters)
- Scientists pinpoint age-related errors in human eggs: "As egg cells mature in older women, researchers have found that pairs of chromosomes separate at the wrong time, leading to early division of chromosomes and incorrect segregation of into mature cells. Eggs that form with the wrong number of chromosomes often result in miscarriage or genetic diseases such as Down syndrome (Nature Communications)…." (Stephen Feller, United Press International)
- Direct link between wound healing, skin cancer seen by researchers: "Researchers have found that inflammatory cells sent by the immune system to the site of a wound for healing are redirected to pre-cancerous cells they help grow. While tissue damage and cancer have been linked before, researchers have now seen inflammatory cells called neutrophils be diverted from wounds to pre-cancerous cells in adult zebrafish (The EMBO Journal)…." (Stephen Feller, United Press International)
- Lack of toilets for 2.4 billion people undermining health efforts: "Lack of access to toilets and unsanitary social norms threaten to undermine global efforts to improve drinking water and increase rates of child survival…." (Stephen Feller, United Press International)
- An important victory against AIDS: Cuba first to end mother-to-child transmission of HIV: "Cuba on Tuesday earned the distinction of becoming the first country to eliminate mother-to-child transmission of the HIV virus, an achievement that global public health officials said they hoped would inspire others to invest in campaigns and policies to try to do the same…." (Ariana Eunjung Cha, Washington Post)
Tuesday June 30, 2015
- Report Urges Major Steps to Help Victims of Cardiac Arrest: "Would you know what to do if you see someone collapse, not breathing - a loved one at home, a co-worker at the office, a stranger on the street? Far too many Americans die of cardiac arrest, and now a major new report guidelines (IOM Report) urges a national campaign to improve survival in part by making sure more bystanders know how…." (Lauran Neergaard, Associated Press)
- A First: New Guidelines Back Device For Treating Strokes: "Many stroke patients have a new treatment option (AP) -- if they seek help fast enough to get it. New guidelines (Circulation) endorse using a removable stent to open clogged arteries causing a stroke…." (Marilynn Marchione, Associated Press)
- Report Shows Widespread Mistreatment by Health Workers During Childbirth: "They are slapped and pinched during labor, yelled at, denied pain medicine, neglected and forced to share beds with other women who just gave birth. And that is just a partial list of the abuses and humiliations inflicted on women around the world as their babies are born. A new report (PLOS Medicine) based on information from 34 countries…." (Denise Grady, New York Times)
- Kids starting school will be required to have dental screenings: "Oregon children who are starting public school and are 7 years old or younger will be required to have dental screenings, or show proof they've had one, under legislation signed by Gov. Kate Brown…." (Amy Wang, The Oregonian)
- Liberia records Ebola death despite being declared virus-free: "A Liberian teenager has died of Ebola, more than seven weeks after the west African country was declared free of the virus, a government minister said on Tuesday.…." (Alphonso Toweh, Reuters)
- Beware of animal diseases as biological weapons, health experts say: "The World Health Organization, animal health and national defense officers called on Tuesday for wider international cooperation to avoid the spread of animal diseases that could be used as biological weapons. Sixty percent of human diseases come from animal agents and 80 percent of the agents that could be used for bio terrorism are of animal origin…." (Sybille de La Hamaide, Reuters)
- California bill to limit vaccine exemptions goes to governor: "California lawmakers on Monday sent Governor Jerry Brown a bill to substantially limit vaccine exemptions for school children in the most populous U.S. state, following last year's measles outbreak at Disneyland that sickened more than 100 people…." (Sharon Bernstein, Reuters)
- Citrus fruit linked with melanoma in preliminary study: "Using data from two long-term studies of women and men, researchers found a potential link between citrus consumption and malignant melanoma of the skin. But the study (Journal of Clinical Oncology) did not test whether citrus fruits were the cause of the skin cancers, and more work will be needed…." (Kathryn Doyle, Reuters)
- Few people heading toward diabetes know it: "Only about one in eight people with so-called pre-diabetes, often a precursor to full-blown disease, know they have a problem, a U.S. study (American Journal of Preventative Medicine) found…." (Lisa Rapaport, Reuters)
- Inherited form of obesity, diabetes discovered: "Researchers have identified a specific genetic change that prevents the body from producing a protein important for processing a number of hormones and brain transmitters controlling appetite, insulin and other hormones important in the reproductive system (PLOS One)…." (Stephen Feller, United Press International)
- Hippocampus shrinks in patients with recurrent depression: "A new study (Molecular Psychiatry) has found that people with major depressive disorder, recurring bouts of depression over the course of one's lifetime, have a smaller hippocampus than people who do not have the disorder…." (Stephen Feller, United Press International)
- Researchers discover what powers enzyme that helps cancer grow: "Researchers have discovered the protein that allows the enzyme ADAM17 to remove molecules from the surface of cancer cells, helping them to grow (Nature Communications)…." (Stephen Feller, United Press International)
- Umbilical cord 'milking' improves blood flow in preterm infants: "Increasing the flow of blood into a prematurely born infants' circulatory system from the umbilical cord has been shown in a study (Pediatrics) to improve blood pressure and red blood cell levels, and can prevent bleeding in the brain…." (Stephen Feller, United Press International)
- Food poisoning from toxin in tropical reef fish is more common than previously thought: " A pesky toxin found in barracuda and other tropical fish has been sickening more people than previously thought, according to a study published Monday by the American Journal of Tropical Medicine and Hygiene. Ciguatera can't be cooked or frozen out of infected fish. You can't smell it or see it with the naked eye, either. And while…." (Elahe Izadi, Washington Post)
- CDC HEALTH ADVISORY (CDC HAN 0360 January 15, 2014): Human Infection with Avian Influenza A (H5N1) Virus
New Resources on MolecularHUB.org
- Healthmap: HealthMap, a team of researchers, epidemiologists and software developers at Boston Children's Hospital founded in 2006, is an established global leader in utilizing online informal sources for disease outbreak monitoring and real-time surveillance of emerging public health threats. The freely available Web site 'healthmap.org' and mobile app 'Outbreaks Near Me' deliver real-time intelligence on a broad range of emerging infectious diseases for a diverse audience including libraries, local health departments, governments, and international travelers. .
- dbGaP: The database of Genotypes and Phenotypes (dbGaP) was developed to archive and distribute the results of studies that have investigated the interaction of genotype and phenotype.
- Personal Genome Project UK: Personal Genome Project UK: Almost all current public data from PGP sites is from the Harvard site. As new sites grow we expect to share more data from around the world.
- Harvard PGP Data: In addition to whole genome sequencing, the Harvard PGP has a variety of donated genetic data (ranging from externally-performed genomes and exomes to direct-to-consumer genotyping).
- E-Bug: A place for children, teens, and adults to play games and learn about microbes.
- 100K Food Pathogen Project: In the Genome Project for Food Pathogens project, FDA has partnered with U.C. Davis and Agilent to map the DNA of 100,000 pathogen strains to stop foodborne illness outbreaks faster.
- Cellminer: CellMiner™ is a web application generated by the Genomics & Bioinformatics Group, LMP, CCR, NCI that facilitates systems biology through the retrieval and integration of the molecular and pharmacological data sets for the NCI-60 cell lines. The NCI-60, a panel of 60 diverse human cancer cell lines used by the Developmental Therapeutics Program of the U.S. National Cancer Institute to screen over 100,000 chemical compounds and natural products (since 1990)
- BAM files: Index of /projects/nci60/wes/BAMS/
- DTP Drug Screen: The In Vitro Cell Line Screening Project (IVCLSP) is a dedicated service providing direct support to the DTP anticancer drug discovery program.
- DTP Molecular Targets: Thousands of molecular targets have been measured in the NCI panel of 60 human tumor cell lines. Measurements include protein levels, RNA measurements, mutation status and enzyme activity levels. You can choose to search for a target of interest, or you may browse through a list of targets. Follow the links for a target to retrieve the 60 cell line data (either text or graphical), to run COMPARE (find Targets or Compounds whose patterns correlate with a Target of interest) and to link to various databases with information (function, sequences, disease associations) about the target
- Influenza Primer Design Resource: A program from Medical College of Wisconsin designed to aid researchers in translating the vast amounts of influenza sequence information into highly effective influenza diagnostics. IPDR consists of a database of all influenza nucleotide sequences and variety of bioinformatic analyses that aid in the development of primers and probes that can be used in diagnostic assays
Other Purdue News and Websites
- Oncological Sciences Center
- Indiana Clinical and Translational Sciences Institute (CTSI): accelerating clinical and translational research in healthcare
- cceHUB.org: Cancer care engineering
- CatalyzeCare.org: Transforming healthcare delivery
- The Center for Global Research and Intervention in Infectious Disease (C-GRIID)
- nanoHUB.org: A resource for nanoscience and nanotechnology, nanoHUB.org was created by the NSF-funded Network for Computational Nanotechnology
- pharmaHUB.org: pharmaHUB was created as an NSF-funded Engineering Virtual Organization with a mission to facilitate collaborative creation and sharing of information, knowledge and modeling tools that support innovations in product and process development and manufacturing methodology for pharmaceutical products
- Communities and Universities Addressing Health Disparities (CUAHD.org) : CUAHD (Communities and Universities Addressing Health Disparities) is a collaboration between Purdue University, the Indiana Minority Health Coalition (IMHC), and the African American communities in Lake and Marion Counties of Indiana working to address the disparities in heart health in the African American community