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Besides the NIH, Van Andel Research Institute, and the Michael J. Fox Foundation, what are other institutions, foundations, organizations, etc. tha…
Does anyone have data that would link the U.S. Affordable Care Act to cost savings for molecular diagnostic tools? If so, could you plea…
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A smell test could someday be one of the tools to screen for people at risk of developing Parkinson's disease, according to a new Mayo Clinic study
Calendar of Events
Molecular Science in the News
(For more information on the below articles, a subscription to the newspaper (and journal) may be required)
Monday August 24, 2015
- With many Ebola survivors ailing, doctors evaluate situation: "Lingering health problems afflicting many of the roughly 13,000 Ebola survivors have galvanized global and local health officials to find out how widespread the ailments are, and how to remedy them. The World Health Organization calls it an emergency within an emergency…." (Carley Petesch, Associated Press)
- Study: Breastfed infants exposed to toxic chemicals: "Breast is considered best when feeding an infant, however researchers found a group of chemicals called perfluorinated alkylate substances, or PFASs, is transferred to babies through breast milk and builds up in their systems. While the study (Environmental Science and Technology) showed the chemical builds up over time as children are breastfed, researchers are unsure of the effect of the chemicals -- levels of which begin falling when children are no longer breastfed…." (Stephen Feller, United Press International)
- Heart medication shown to improve ovarian cancer patient survival: "In a retrospective review of medical records, researchers found that ovarian cancer patients also taking beta blockers for heart disease had longer survival rates than those who were not taking the drugs (Cancer)…." (Stephen Feller, United Press International)
- Study sparks debate on treatment for early stage breast cancer: "A new study released Thursday sparked a debate on the importance of treatment options for women diagnosed with the earliest stage of breast cancer. The study (JAMA Oncology)found that treatment such as radiation for women diagnosed with with DCIS — ductal carcinoma in situ — or stage 0 breast cancer does not eliminate the threat of breast cancer at 10 years. However, researchers studied 100,000 women diagnosed with DCIS for 20 years, and found 97% of them did not die from breast cancer after undergoing treatment…." (Jennifer Calfas, USA Today)
- New Ways for Patients to Get a Second Opinion: "For many patients, it has become a routine part of the medical process: Get a diagnosis or treatment plan and then seek a second opinion. A growing number of online services are offering second opinions and some are seeing increasing patient demand for a second set of eyes…." (Sumathi Reddy, Wall Street Journal)
- Vaccine Injury Payouts Rise: "A government program that pays people hurt by vaccinations recently doled out more than $1 million to Latasha George, a Louisiana nurse. Katherine Brooks, an Indiana emergency-room doctor, received $92,500. Roberta Livolsi, a retired Pennsylvania housekeeper, got $75,000. All were deemed victims of the flu shot—but their injuries had nothing to do with what was in the syringe. The patients were among dozens that have been diagnosed with “Sirva,” or shoulder injury related to vaccine administration…." (Ianthe Jeanne Duran, Wall Street Journal)
- 1 in 5 senior citizens drinking ‘unsafe’ levels of alcohol: "Never mind the college kids. A sizable chunk of senior citizens are drinking at "unsafe" levels, which could have serious consequences for their health, according to British researchers (BMJ Open)…." (Brady Dennis, Washington Post)
Friday August 7, 2015
- Meningitis epidemic threat in West Africa, but few vaccines: "International health officials are scrambling, without much success, to find meningitis C vaccines as an outbreak of the child-killing disease threatens to balloon into an epidemic. The first large-scale outbreak of the C strain in decades has this year killed 800 of 12,000 infected people in Nigeria and in neighboring Niger, according to the World Health Organization…." (Caelainn Hogan, Associated Press)
- Hepatitis increasingly goes hand in hand with heroin abuse: "Public health agencies and drug treatment centers nationwide are scrambling to battle an explosive increase in cases of hepatitis C, a scourge they believe stems at least in part from a surge in intravenous heroin use…." (Patrick Whittle, Associated Press)
- Obama administration plans new workplace limits on beryllium: "The Obama administration is proposing new safety rules to limit workplace exposure to beryllium, a type of metal used in aerospace, electronics and other industries that can cause serious health problems when it's ground into dust and inhaled…." (Associated Press)
- Pfizer, Bristol revive cancer drugs that rev up immune system: "Some of the most heralded new cancer drugs fight the disease by removing brakes on the immune system. Now a few leading drugmakers are paying attention to a second, opposing force: medicines that accelerate the immune system's attack…." (Bill Berkrot, Reuters)
- Thousands of Ebola survivors face severe pain, possible blindness: "Thousands of West Africans who were infected with the Ebola virus but survived it are suffering chronic conditions such as serious joint pain and eye inflammation that can lead to blindness, global health experts said on Friday. Ebola survivors who fought off the most severe bouts of infection are the most likely to suffer ongoing medical problems, World Health Organization experts said, and their health is becoming "an emergency within an emergency"…." (Kate Kelland, Reuters)
- Sanofi links with Evotec to tap stem cells for diabetes care: "French drugmaker Sanofi is linking with Evotec to develop stem cell-based treatments for diabetes, under a deal that could earn the German biotech firm more than 300 million euros ($327 million). Sanofi, a leading supplier of diabetes care, said on Friday the aim was develop beta cell-modulating diabetes therapies that could reduce or eliminate the need for insulin injections…." (Ben Hirschler, Reuters)
- Study: Legionnaire's disease cases tripled in last decade: "Officials in New York City say the Legionnaires' disease outbreak the city has dealt with for the last month -- at least 10 deaths and more than 100 confirmed cases -- appears to be winding down, but national health statistics in the U.S. show cases of the disease have tripled during the last decade (Journal of Public Health Management and Practice)…." (Stephen Feller, United Press International)
- High numbers of hepatitis C infections found at urban ERs: "Three-quarters of people who tested positive for the hepatitis C virus in a study (Annals of Emergency Medicine) of patients at emergency rooms had no idea they were infected with it…." (Stephen Feller, United Press International)
- Researchers show how single genetic mutation can cause autism: "While studying the development of a rare neurological disorder called Angelman syndrome, researchers discovered the way one specific genetic mutation can cause autism -- and they may have a treatment to reverse it (Cell) …." (Stephen Feller, United Press International)
- Researchers link gut bacteria to type 1 diabetes: "Researchers have found gut bacteria may play a role in the prevention and regulation of type 1 diabetes. Researchers at the National Institute of Health and Medical Research (INSERM) in France saw that antimicrobial peptides called cathelicidins are not produced by beta pancreatic cells, which secrete insulin, in mice with diabetes, but can be found in mice without diabetes. (Cell: Immunity) …." (Stephen Feller, United Press International)
- Study: Most teens start school too early in morning to get enough sleep: "Most teens start school too early in the morning, which deprives them of the sleep they need to learn and stay healthy, a new study says. The American Academy of Pediatrics last year urged middle schools and high schools to start no earlier than 8:30 a.m. in order to allow teens — who are biologically programmed to stay up later at night than adults — to get the recommended 8.5 to 9.5 hours of sleep each night. But 83% of schools do start before 8:30 a.m., according to a study (MMWR) released Thursday by the Centers for Disease Control and Prevention…." (Liz Szabo, USA Today)
- Drug-Plan Managers Wield ‘Potent Weapon’: "CVS Health Corp. ’s decision to stop covering Pfizer Inc. ’s anti-impotence pill Viagra for many of its drug-benefit plan members is the latest example of the tough tactics some health-care managers are using to control rising drug costs. CVS and rival Express Scripts Holding Co. , which together dominate the U.S. market for administering drug-benefit plans for employers and insurers, are excluding more drugs from coverage if there are viable alternatives in attempts to squeeze greater price discounts from manufacturers…." (Peter Loftus, Wall Street Journal)
- NYC Legionnaires’ disease death toll hits double-digits as officials order inspection of all cooling towers, threaten penalties: "New York City officials have launched aggressive measures to stop the spread of Legionnaires' disease, threatening to charge owners of buildings with cooling towers with a misdemeanor if they don't test and disinfect them within the next 14 days…." (Ariana Eunjung Cha, Washington Post)
- Even short term use of birth control pills can lower uterine cancer risk decades later, study says: "When it comes to the impact of oral contraceptives on cancer risk, the picture is mind-numbingly confusing. One large analysis showed that the pill can slightly increase your risk of breast cancer. But there's evidence your risk might go back to normal 10 years after you stop taking it. A few studies have shown a link to a heightened in the risk of cervical cancer. But no one's quite sure because taking the pill is also associated to an increase in sexual activity, which could also lead to cervical cancer. The latest research (Lancet Oncology) looks at birth control pills and cancers of the womb and finds…." (Ariana Eunjung Cha, Washington Post)
Thursday August 6, 2015
- Boston Mayor Wants Ban on Chewing Tobacco at Ballparks: "From storied Fenway Park to youth baseball diamonds across the city, Boston Mayor Martin J. Walsh is calling for a ban on dip, snuff and chewing tobacco…." (Philip Marcelo, Associated Press)
- Colorado Resident is 2nd to Die of Plague There This Year: "A person from southern Colorado has died of the plague, the second person to die of the disease in the state this year…." (Associated Press)
- Food Industry Asks For Exemptions to Trans Fat Phase Out: "Shortening, pie crusts, brownies and microwave popcorn could be partially exempt from a government phase out of artificial trans fats - if the food industry gets its way…." (Mary Clare Jalonick, Associated Press)
- New Ebola Cases in Single Digits Another Week, Says WHO: "New Ebola cases were in the single digits another week, the World Health Organization said Wednesday, showing that contact tracing efforts are yielding results…." (Carley Petesch, Associated Press)
- New York Legionnaires' deaths rise to eight, nearly 100 sickened: "The number of deaths from an outbreak of Legionnaires' disease in New York has risen to eight and 97 people were reported sick with it, according to statistics released by Mayor Bill de Blasio's office…." (Suzannah Gonzales, Reuters)
- Low scores on thinking-skills tests may signal heart attack risk: "For older people without dementia, fuzzy thinking and lack of self control may be signs of higher risk for heart attack or stroke, a new European study (Neurology)suggests…." (Kathryn Doyle, Reuters)
- Intra-abdominal fat may play role in IBD development: "Intra-abdominal fat, which wraps around the intestine, may be involved in the development of inflammatory bowel disease, or IBD, according to research from the University of California Los Angeles. Researchers said the study (Cellular and Molecular Gastroenterology and Hepatology) is the first to show different disease-dependent responses from fat cells to inflammatory mediators…." (Stephen Feller, United Press International)
- Infant mortality rate hits record low, although racial disparities persist: "The USA’s infant mortality rate hit a record low in 2013, falling to 5.96 deaths per 1,000 live births, or about 23,400 deaths, according to a report issued Thursday. While health officials cheered those new numbers, they noted that the USA still lags behind other nations and that mortality among black babies is far higher than among whites. Infant mortality in the USA has dropped 13% since 2005, according to the National Center for Health Statistics (National Vital Statistics Reports)…." (Liz Szabo, USA Today)
- CDC HEALTH ADVISORY (CDC HAN 0360 January 15, 2014): Human Infection with Avian Influenza A (H5N1) Virus
New Resources on MolecularHUB.org
- Healthmap: HealthMap, a team of researchers, epidemiologists and software developers at Boston Children's Hospital founded in 2006, is an established global leader in utilizing online informal sources for disease outbreak monitoring and real-time surveillance of emerging public health threats. The freely available Web site 'healthmap.org' and mobile app 'Outbreaks Near Me' deliver real-time intelligence on a broad range of emerging infectious diseases for a diverse audience including libraries, local health departments, governments, and international travelers. .
- dbGaP: The database of Genotypes and Phenotypes (dbGaP) was developed to archive and distribute the results of studies that have investigated the interaction of genotype and phenotype.
- Personal Genome Project UK: Personal Genome Project UK: Almost all current public data from PGP sites is from the Harvard site. As new sites grow we expect to share more data from around the world.
- Harvard PGP Data: In addition to whole genome sequencing, the Harvard PGP has a variety of donated genetic data (ranging from externally-performed genomes and exomes to direct-to-consumer genotyping).
- E-Bug: A place for children, teens, and adults to play games and learn about microbes.
- 100K Food Pathogen Project: In the Genome Project for Food Pathogens project, FDA has partnered with U.C. Davis and Agilent to map the DNA of 100,000 pathogen strains to stop foodborne illness outbreaks faster.
- Cellminer: CellMiner™ is a web application generated by the Genomics & Bioinformatics Group, LMP, CCR, NCI that facilitates systems biology through the retrieval and integration of the molecular and pharmacological data sets for the NCI-60 cell lines. The NCI-60, a panel of 60 diverse human cancer cell lines used by the Developmental Therapeutics Program of the U.S. National Cancer Institute to screen over 100,000 chemical compounds and natural products (since 1990)
- BAM files: Index of /projects/nci60/wes/BAMS/
- DTP Drug Screen: The In Vitro Cell Line Screening Project (IVCLSP) is a dedicated service providing direct support to the DTP anticancer drug discovery program.
- DTP Molecular Targets: Thousands of molecular targets have been measured in the NCI panel of 60 human tumor cell lines. Measurements include protein levels, RNA measurements, mutation status and enzyme activity levels. You can choose to search for a target of interest, or you may browse through a list of targets. Follow the links for a target to retrieve the 60 cell line data (either text or graphical), to run COMPARE (find Targets or Compounds whose patterns correlate with a Target of interest) and to link to various databases with information (function, sequences, disease associations) about the target
- Influenza Primer Design Resource: A program from Medical College of Wisconsin designed to aid researchers in translating the vast amounts of influenza sequence information into highly effective influenza diagnostics. IPDR consists of a database of all influenza nucleotide sequences and variety of bioinformatic analyses that aid in the development of primers and probes that can be used in diagnostic assays
Other Purdue News and Websites
- Oncological Sciences Center
- Indiana Clinical and Translational Sciences Institute (CTSI): accelerating clinical and translational research in healthcare
- cceHUB.org: Cancer care engineering
- CatalyzeCare.org: Transforming healthcare delivery
- The Center for Global Research and Intervention in Infectious Disease (C-GRIID)
- nanoHUB.org: A resource for nanoscience and nanotechnology, nanoHUB.org was created by the NSF-funded Network for Computational Nanotechnology
- pharmaHUB.org: pharmaHUB was created as an NSF-funded Engineering Virtual Organization with a mission to facilitate collaborative creation and sharing of information, knowledge and modeling tools that support innovations in product and process development and manufacturing methodology for pharmaceutical products
- Communities and Universities Addressing Health Disparities (CUAHD.org) : CUAHD (Communities and Universities Addressing Health Disparities) is a collaboration between Purdue University, the Indiana Minority Health Coalition (IMHC), and the African American communities in Lake and Marion Counties of Indiana working to address the disparities in heart health in the African American community