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The US is currently experiencing an outbreak of measles in over 14 states, many cases linking back to California's Disneyland which start…
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Lung cancer is the most common cancer killer of both men and women, and there is a 30 to 40 percent higher incidence of being diagnosed for African American men.
Calendar of Events
Molecular Science in the News
(For more information on the below articles, a subscription to the newspaper (and journal) may be required)
Friday April 17, 2015
- Clues to How an Electric Treatment for Parkinson’s Works : " In 1998, Dr. Philip A. Starr started putting electrodes in people’s brains. A neurosurgeon at the University of California, San Francisco, Dr. Starr was treating people with Parkinson’s disease, which slowly destroys essential bits of brain tissue, robbing people of control of their bodies. At first, drugs had given his patients some relief, but now they needed more help…." (Carl Zimmer, New York Times)
- Generic Version of Copaxone, Multiple Sclerosis Drug, Is Approved : " The Food and Drug Administration on Thursday approved the first generic substitute for Copaxone, a widely used drug for multiple sclerosis and the biggest-selling product for Teva Pharmaceutical Industries. The approval of the generic, which was developed by the team of Sandoz and Momenta Pharmaceuticals — could bring some price competition to the market for multiple sclerosis drugs. …." (Andrew Pollack, New York Times)
- Ebola Researchers Take New Look at Risk of Sexual Transmission : " Concerned about the potential for sexual transmission of Ebola, international health officials are investigating new reports of suspected cases and beginning studies to determine how often and how long the virus remains active in semen. And, for now, they are warning Ebola survivors to practice protected sex indefinitely…." (Sheri Fink, New York Times)
- 'Exhausted' Liberia struggles with long Ebola 'to do' list : " Treating trauma and the mental health issues of Ebola survivors is one of the many challenges facing "exhausted" Liberia, a senior health ministry official said. Liberia has weathered the worst ever outbreak of Ebola, which has killed more than 10,600 people and infected 25,791, more successfully than its neighbors Sierra Leone and Guinea…." (Astrid Zweynert, Reuters)
- A dog's life: study reveals people's hormonal link with tail-waggers : " Dogs are called "man's best friend" - women's, too - and scientists say the bond between people and their pooches may be deeper than you might think. Researchers in Japan (Science Magazine ) said on Thursday oxytocin, a hormone that among other things helps reinforce bonds between parents and their babies, increases in humans and their dogs when they interact, particularly when looking into one another's eyes…." (Will Dunham, Reuters)
- Maple syrup extract may boost effectiveness of antibiotics : " A new study (Applied and Environmental Microbiology ) showed maple syrup extract made bacteria more vulnerable to the germ-fighting effects of antibiotics. Researchers at McGill University, in Montreal, Canada, found that condensed maple syrup weakened microbial defense systems, allowing antibiotics to work more efficiently…." (Brooks Hays, United Press International)
Thursday April 16, 2015
- Study: Many Medicare Cataract Patients Given Needless Tests: "Millions of older people are getting tests they don't need to prove they are healthy enough to have cataracts removed, a new study (New England Journal of Medicine) finds. The excess testing before this quick, ultra-safe eye procedure is costing them and Medicare a bundle, and many patients don't know they can question it, doctors say…." (Marilynn Marchione, Associated Press)
- Use of E-Cigarettes Rises Sharply Among Teenagers, Report Says: "Use of the devices among middle- and high school students tripled from 2013 to 2014, according to federal data (Centers for Disease Control and Prevention) released on Thursday, bringing the share of high school students who use them to 13 percent — more than smoke traditional cigarettes. The sharp rise, together with a substantial increase in the use of hookah pipes, led to 400,000 additional young people using a tobacco product in 2014….…." (Sabrina Travernise, New York Times)
- As Ebola Retreats, Obama Urges Vigilance and Preparation in West Africa: "Now that the Ebola crisis in West Africa finally appears to be petering out, President Obama on Wednesday called for renewed international efforts to rebuild the shattered health systems in Liberia, Guinea and Sierra Leone, to shore up the response to future pandemics in the region.…." (Helene Cooper, New York Times)
- Type 2 diabetes with depression boosts risk of dementia: "It’s already known that people with Type 2 diabetes and those with depression each face a greater risk of dementia. But now a study published online Wednesday in JAMA Psychiatry says people with both conditions face a risk of dementia higher than expected…." (David Templeton, Pittsburgh Post-Gazette)
- California officials may declare end of Disneyland-linked measles outbreak: "A measles outbreak in California that has been traced to Disneyland in December and renewed a debate over the anti-vaccination movement would be declared over on Friday if no new related cases arise, a public health official said on Thursday.…." (Eric M Johnson, Reuters)
Wednesday April 15, 2015
- Official: 43 now taking part in Indiana needle-exchange push: "An SUV staffed with health workers on a quest to provide clean needles to intravenous drug users has begun making the rounds in a small Indiana city at the center of an HIV outbreak, officials said Tuesday…." (Rick Callahan, Associated Press)
- FDA panel wants heart failure risk on AstraZeneca drugs: "Federal health advisers say AstraZeneca's Onglyza and a related diabetes drug should carry new information about a possible association with heart failure and death. The Food and Drug Administration's panel of diabetes experts voiced concern about data suggesting Onglyza and Kombiglyze can increase hospitalization due to heart failure and overall mortality. The panel voted 14-1 that that information should appear on the drugs' prescribing labeling…." (Matthew Perrone, Associated Press)
- Senate Approves a Bill on Changes to Medicare: "The Senate on Tuesday overwhelmingly approved sweeping changes in the way Medicare pays doctors, clearing the bill for President Obama and resolving an issue that has bedeviled Congress and the Medicare program for more than a decade…." (Robert Pear, New York Times)
- We can actually train our eyes to see better, study discovers: "Use it or lose it. That's a common phrase employed to get people up off the couch and moving. The meaning is obvious enough: if you want to stay physically fit, you have to work your muscles. Could it also apply to your eyes? Conventional wisdom long has been that our eyes deteriorate as we age, and there's nothing we can do about it. A study newly published in Psychological Science, however, has discovered…." (Douglas Perry, The Oregonian)
- Childhood trauma may raise risk of type 1 diabetes: "Traumatic events during childhood may increase kids' risk of developing type 1 diabetes, a Swedish study (Diabetologia) suggests. The researchers questioned more than 10,000 families and found that children who experienced an extremely stressful life event – like divorce, illness or death in the family – were about three times more likely to develop type 1 diabetes…." (Lisa Rapaport, Reuters)
- Chicago-area dog flu cases climb to over 1,100, including six deaths: "At least 1,137 Chicago-area dogs have come down with a highly contagious strain of canine flu, and six have died, in the largest and longest-lasting dog flu outbreak ever seen in the region, county officials said on Tuesday. Veterinarians began reporting cases of Canine Infectious Respiratory Disease, or CIRD, in January, said Cook County spokesman Frank Shuftan. There may be more cases than have been reported, Shuftan said…." (Mary Wisniewski, Reuters)
- More U.S. poultry flocks infected with bird flu: Agriculture Department: "The number of U.S. poultry flocks infected with a deadly strain of bird flu rose on Tuesday as Iowa identified its first case and Minnesota confirmed eight more cases, according to the U.S. Department of Agriculture…." (Tom Polansek, Reuters)
- Report: Medical data breaches are rising, with no end in sight: "High-profile health care data breaches, like the recent attack on medical insurance giant Anthem that compromised the personal information of as many as 80 million Americans, are on the rise and expected to increase with the use of new technologies employed by criminals, a study (JAMA) by Kaiser Permanente researchers has found…." (Victoria Colliver, San Francisco Chronicle)
- Paternal sperm offers clues to autism: "Could the specifics of a father's sperm offer clues to the causes of autism? Researchers at John Hopkins Medicine say yes. Because most instances of autism are believed to be inherited, scientists thought it might be prudent to look at the earliest of genetic instructions -- the working manual inside paternal sperm (International Journal of Epidemiology)…." (Brooks Hays, United Press International)
- Five days of fatty foods alters how the body processes nutrients: "Most nutritionists agree it's okay to indulge now and then. Even the healthiest of eaters have their weaknesses. But new research (Obesity) shows just how quickly a poor diet can alter the insides…." (Brooks Hays, United Press International)
- Reports to Feds on deadly bacteria outbreaks arrived late: "Reports alerting federal officials that contaminated medical scopes appeared to be spreading deadly superbugs among hospital patients sometimes arrived months late – or not at all, according to federal records and interviews…." (Peter Eisler, USA Today)
- CDC HEALTH ADVISORY (CDC HAN 0360 January 15, 2014): Human Infection with Avian Influenza A (H5N1) Virus
New Resources on MolecularHUB.org
- Healthmap: HealthMap, a team of researchers, epidemiologists and software developers at Boston Children's Hospital founded in 2006, is an established global leader in utilizing online informal sources for disease outbreak monitoring and real-time surveillance of emerging public health threats. The freely available Web site 'healthmap.org' and mobile app 'Outbreaks Near Me' deliver real-time intelligence on a broad range of emerging infectious diseases for a diverse audience including libraries, local health departments, governments, and international travelers. .
- dbGaP: The database of Genotypes and Phenotypes (dbGaP) was developed to archive and distribute the results of studies that have investigated the interaction of genotype and phenotype.
- Personal Genome Project UK: Personal Genome Project UK: Almost all current public data from PGP sites is from the Harvard site. As new sites grow we expect to share more data from around the world.
- Harvard PGP Data: In addition to whole genome sequencing, the Harvard PGP has a variety of donated genetic data (ranging from externally-performed genomes and exomes to direct-to-consumer genotyping).
- E-Bug: A place for children, teens, and adults to play games and learn about microbes.
- 100K Food Pathogen Project: In the Genome Project for Food Pathogens project, FDA has partnered with U.C. Davis and Agilent to map the DNA of 100,000 pathogen strains to stop foodborne illness outbreaks faster.
- Cellminer: CellMiner™ is a web application generated by the Genomics & Bioinformatics Group, LMP, CCR, NCI that facilitates systems biology through the retrieval and integration of the molecular and pharmacological data sets for the NCI-60 cell lines. The NCI-60, a panel of 60 diverse human cancer cell lines used by the Developmental Therapeutics Program of the U.S. National Cancer Institute to screen over 100,000 chemical compounds and natural products (since 1990)
- BAM files: Index of /projects/nci60/wes/BAMS/
- DTP Drug Screen: The In Vitro Cell Line Screening Project (IVCLSP) is a dedicated service providing direct support to the DTP anticancer drug discovery program.
- DTP Molecular Targets: Thousands of molecular targets have been measured in the NCI panel of 60 human tumor cell lines. Measurements include protein levels, RNA measurements, mutation status and enzyme activity levels. You can choose to search for a target of interest, or you may browse through a list of targets. Follow the links for a target to retrieve the 60 cell line data (either text or graphical), to run COMPARE (find Targets or Compounds whose patterns correlate with a Target of interest) and to link to various databases with information (function, sequences, disease associations) about the target
- Influenza Primer Design Resource: A program from Medical College of Wisconsin designed to aid researchers in translating the vast amounts of influenza sequence information into highly effective influenza diagnostics. IPDR consists of a database of all influenza nucleotide sequences and variety of bioinformatic analyses that aid in the development of primers and probes that can be used in diagnostic assays
Other Purdue News and Websites
- Oncological Sciences Center
- Indiana Clinical and Translational Sciences Institute (CTSI): accelerating clinical and translational research in healthcare
- cceHUB.org: Cancer care engineering
- CatalyzeCare.org: Transforming healthcare delivery
- The Center for Global Research and Intervention in Infectious Disease (C-GRIID)
- nanoHUB.org: A resource for nanoscience and nanotechnology, nanoHUB.org was created by the NSF-funded Network for Computational Nanotechnology
- pharmaHUB.org: pharmaHUB was created as an NSF-funded Engineering Virtual Organization with a mission to facilitate collaborative creation and sharing of information, knowledge and modeling tools that support innovations in product and process development and manufacturing methodology for pharmaceutical products
- Communities and Universities Addressing Health Disparities (CUAHD.org) : CUAHD (Communities and Universities Addressing Health Disparities) is a collaboration between Purdue University, the Indiana Minority Health Coalition (IMHC), and the African American communities in Lake and Marion Counties of Indiana working to address the disparities in heart health in the African American community