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Besides the NIH, Van Andel Research Institute, and the Michael J. Fox Foundation, what are other institutions, foundations, organizations, etc. tha…
Does anyone have data that would link the U.S. Affordable Care Act to cost savings for molecular diagnostic tools? If so, could you plea…
Video of the Day
A smell test could someday be one of the tools to screen for people at risk of developing Parkinson's disease, according to a new Mayo Clinic study
Calendar of Events
Molecular Science in the News
(For more information on the below articles, a subscription to the newspaper (and journal) may be required)
Friday July 31, 2015
- Only small increase in US girls getting cervical cancer shot: "More U.S. girls are getting a controversial vaccine, but the increase last year was only slight. A national survey (MMWR)released Thursday found 60 percent of adolescent girls received at least one of three doses of the vaccine against human papillomavirus, or HPV. It was 57 percent in 2013…." (Mike Stobbe, Associated Press)
- Feds release updated strategy against AIDS in America: "U.S. health officials have updated their strategic plan for fighting AIDS, setting new goals for reducing infections and deaths. The new document "seizes on the rapid shifts in science as we've learned more about this disease," said President Barack Obama, in a statement…." (Mike Stobbe, Associated Press)
- Sierra Leone faces Ebola setback; 500 under quarantine: " Authorities in Sierra Leone said Thursday they had quarantined 500 people after a man died from Ebola in an area where the deadly virus had been gone for months, in another setback for the fight against the disease…." (Clarence Roy-Macaulay, Associated Press)
- Increased Competition Kept Lid on Health Insurance Inflation, U.S. Says: "The Obama administration said on Thursday that many consumers were benefiting from increased competition among insurers under the Affordable Care Act. Most people who bought insurance through the federal marketplace had a greater choice of health plans this year than in 2014, the administration said, and premiums rose less in counties where more insurers were competing for business…." (Robert Pear, New York Times)
- Liberia: Ebola Stalls Birth Registrations: "The births of more than 70,000 children in Liberia during the Ebola crisis were never recorded, leaving them vulnerable to marginalization as noncitizens, denial of government services, trafficking and illegal adoption, Unicef reported Thursday. …." (Rick Gladstone, New York Times)
- Antibiotic could cause hearing loss in preemies, study indicates: "The drug that cured Peter Steyger of meningitis as a toddler also made him deaf. Now a researcher at Oregon Health & Science University, he just discovered that the the class of drugs used to cure him can strip away hearing. They're often given to infants in neonatal intensive care units (Science Translational Medicine)…." (Lynne Terry, Oregonian)
- Medication may reduce injury risk for kids with ADHD: "Children with attention-deficit hyperactivity disorder (ADHD) are less likely to have accidents that land them in the emergency room than those who are not on medication, according to a new study (Lancet Psychiatry)…." (Kathryn Doyle, Reuters)
- New biomarker, therapeutic target for breast cancer identified: "Researchers have discovered a molecule present in basal-like breast cancer, or BLBC, tumors that allows them to be detected, and when its presence was reduced in cancer cell models the tumors' growth was slowed significantly (Breast Cancer Research)…." (Stephen Feller, United Press International)
- Cancer drug flushes dormant HIV out of hiding in the body: "The active ingredient in a cancer drug was found by researchers to reactivate latent human immunodefiency virus, or HIV, hiding in the body so that it can be killed by the immune system and anti-retroviral drugs (PLOS Pathogens)…." (Stephen Feller, United Press International)
- Software analyzes type, location of fat in body: "Researchers developed software that can detect whether fat in the body is the good brown type or the bad white type, and whether white fat is in subcutaneous cells in the skin or deeper in visceral cells and possibly wrapped around organs…." (Stephen Feller, United Press International)
- Ebola vaccine appears to be highly effective, could be ‘a game-changer’: "The World Health Organization announced Friday that an Ebola vaccine has shown great promise in halting the spread of the deadly virus during a clinical trial in Guinea. "We believe that the world is on the verge of an efficacious Ebola vaccine," Marie-Paule Kieny, WHO assistant director general for health systems and innovation, said in announcing the results of a preliminary study on the vaccine trial (Lancet)…." (Abby Philip, Sarah Larimer,and Joel Achenbach, Washington Post)
- The South has greatest prevalence of disabled adults, new government data show: "Southern states have a higher prevalence of adults with disabilities compared to the rest of the country, according to a report released Thursday from the Centers for Disease Control and Prevention. The report (MMWR), based on a 2013 nationwide survey of about 465,000 people, details for the first time the prevalence of different types of disabilities at the state level, and includes…." (Robert Gebelhoff, Washington Post)
- Scientists are honing a computer model to predict the size and timing of flu outbreaks: "There's no shortage of experts monitoring influenza outbreaks around the globe.The Centers for Disease Control and Prevention tracks flu activity in the United States year round and produces weekly flu activity reports between the peak months of October to May. Likewise, the World Health Organization constantly gathers epidemiological surveillance data, and releases updates on outbreaks taking place anywhere, anytime. Still, despite the monitoring and the annual push to administer flu vaccines, influenza still sickens millions of people around the world each year, leading to as many as 500,000 deaths annually. Young children and the elderly in particular are at risk. But what if we were better at predicting -- and preparing for -- seasonal flu outbreaks?…." (Brady Dennis, Washington Post)
Thursday July 30, 2015
- Planned Parenthood seeks fed study of fetal tissue research: "Under fire for its role in providing fetal tissue for research, Planned Parenthood asked the government's top health scientists Wednesday to convene a panel of independent experts to study the issues…." (Alan Fram, Associated Press)
- When brain-dead organ donors were cooled, their kidneys worked better in transplant recipients: "Allowing brain-dead organ donors’ body temperatures to fall slightly after brain death — rather than following the accepted protocol of keeping donors warmed to a normal body temperature — resulted in more successful kidney transplants in a recent clinical trial, with fewer organ recipients requiring dialysis in their first week after surgery (New England Journal of Medicine)…." (Eryn Brown, Los Angeles Times)
- Legionnaires’ Disease Sickens 31, 2 Fatally, in the South Bronx: "An outbreak of Legionnaires’ disease has sickened 31 people in the South Bronx since July 10, two of them fatally, New York City health officials said on Wednesday. It is the largest flare-up of the disease the city has experienced in at least two years, and the second this year to strike the Bronx…." (Winnie Hu, New York Times)
- New Ebola Cases Decline, but W.H.O. Advises Caution: "Seven new cases of Ebola were reported in Guinea and Sierra Leone last week, the lowest weekly total in more than a year, the World Health Organization said Wednesday. But it is too soon to tell whether the decline will last…." (Denise Grady, New York Times)
- High sodium diet may predict high blood pressure to come: "As dietary sodium levels go up over time, so does the risk for high blood pressure, suggests a new study (Journal of the American Heart Association) that followed more than 4,000 adults in Japan for four years…." (Kathryn Doyle, Reuters)
- Telemedicine can widen access to depression therapy for seniors: "Talk therapy delivered by two-way video call helped older veterans with depression as much as in-person therapy sessions, a U.S. study (The Lancet Psychiatry) found. Many seniors face obstacles to getting help for depression, including mobility issues and fear of social stigma, researchers say, so telemedicine might expand their access to treatment. “Psychotherapy works for depression whether you deliver it by face-to-face or the telemedicine approach,” and telemedicine is a good option…." (Madeline Kennedy, Reuters)
- Live imaging of lung cancer cells during surgery improves precision: "Researchers used a targeted molecular contrast agent to make tumors glow to the naked eye, making it easier to identify tumors during surgery. During two surgeries that were part of a study testing the tumor identification method, doctors found secondary tumors they did not know were there (Journal of Thoracic and Cardiovascular Surgery)…." (Stephen Feller, United Press International)
- Five subtypes of prostate cancer identified, paving way for more personalized treatments: "Through genomic profiling of 259 men with prostate cancer, scientists have identified five groups of prostate cancer with distinct DNA signatures. The discovery represents a major advance as researchers can now begin trying to tailor therapies to those subtypes. The approach has worked well in breast cancer and helped millions avoid the unnecessary cost, pain and time spent on treatments that are destined to fail (EBio Medicine)…." (Ariana Eunjung Cha, Washington Post)
- How drones can improve medical care access: "Drones seem perfect for quick and fast delivery of all sorts of cargo. So why not biomedical specimens? Well, before the medical community goes down that road, researchers with the Johns Hopkins University School of Medicine wanted to know whether an actual drone flight, including a shaky takeoff and bumpy landing, would affect the specimens. So they tested it in a proof-of-concept study (PLOS One)…." (Elahe Izadi, Washington Post)
- Next stop for IBM’s Watson supercomputer: Your local CVS pharmacy: "IBM is teaming with CVS Health to harness the power of the Watson supercomputing brain to transform how the care of patients with chronic conditions is managed. Under a deal expected to be announced Thursday, the companies will work to develop a system that would be able to provide better personalization of care, prevent the use of unneeded and costly interventions, and even predict health declines for a wide range of conditions including…." (Ariana Eunjung Cha, Washington Post)
Wednesday July 29, 2015
- Then & Now: Medicare and Medicaid turn 50: "When President Lyndon B. Johnson signed Medicare and Medicaid into law on July 30, 1965, roughly half of Americans 65 and older had no health insurance…." (Ricardo Alonso-Zaldivar, Associated Press)
- Health care spending to accelerate, US report says: "It's lasted six years. But now welcome relief from rising U.S. health care costs seems to be winding down. Health care spending will outpace the nation's overall economic growth over the next decade, the government forecast on Tuesday, highlighting a challenge for the next president, not to mention taxpayers, businesses and individual Americans (Health Affairs)…." (Ricardo Alonso-Zaldivar, Associated Press)
- Immigrants, poor fish for their dinner, unaware of mercury: "It's midday and the white bucket balanced on the rocky shore at Mountha Uppasay's feet holds five or six white bass, moving sluggishly in the water she scooped from the Des Moines River. She and her husband, who are immigrants from Laos, have been fishing since shortly after dawn and plan to catch enough to make a tasty stew to share with their children and grandchildren. Asked about possible health issues with the fish, Uppasay flashes a surprised look and says, "They're all safe."…." (Scott McFetridge, Associated Press)
- Sanofi's combination diabetes drug hits goal in late-stage trial: "Sanofi said on Wednesday a first late-stage Phase III study of its LixiLan diabetes drug had met its main target, while another would be completed at the end of the third quarter…." (Matthias Blamont, Reuters)
- Iowa extends bird flu disaster proclamation through August: "Iowa Governor Terry Branstad on Tuesday extended the state's bird flu disaster proclamation by a month until Aug. 30, keeping in place a raft of state resources for poultry farms recovering from an outbreak of the disease, country's worst-ever. …." (Karl Plume, Reuters)
- Skipping breakfast may be bad for diabetics: "People with type 2 diabetes who skip breakfast and fast until noon may have blood sugar spikes throughout the day, a small study (Diabetes Care) suggests. When 22 patients with type 2 diabetes missed their morning meal, they had higher-than-usual surges in blood sugar after lunch and dinner, the study found…." (Lisa Rapaport, Reuters)
- New tool helps match cancer patients with most ideal drugs: "A new tool (Genomics of Drug Sensitivity in Cancer Database)could help doctors treat cancer patients by choosing the most effective combination of drugs by considering the genetic sensitivities of a tumor and the "spillover" benefits of drugs for a specific patient's cancer (Bioinformatics)…." (Stephen Feller, United Press International)
- Spinal cord stimulation more effective at higher frequency: "High-frequency spinal cord stimulation had nearly twice the effectiveness for chronic back and leg pain patients as traditional low frequency stimulation in a recent study (Anesthesiology)…." (Stephen Feller, United Press International)
- Big swings in blood pressure may indicate heart problems: "Large swings in blood pressure may be indicative of damage to the arteries, heart disease or heart failure, according a large study (Annals of Internal Medicine) of patients taking blood pressure medications. While about 1 in 3 Americans have high blood pressure, which can be indicative of the same conditions, blood pressure should remain stable over time…." (Stephen Feller, United Press International)
- Deep brain stimulation fails to improve depression symptoms in trial: "The results of the first large-scale clinical trial (Biological Psychology) using deep brain stimulation, or DBS, to treat depression failed to show a significant improvement in symptoms. DBS has previously been shown in smaller studies to be effective for depression and obsessive-compulsive disorder, and has been shown to be highly effective in treating Parkinson's disease, essential tremor, and other neurologic conditions…." (Stephen Feller, United Press International)
- Sources: EPA will ease deadlines on pollution rule to help states comply: "The Obama administration has decided to give states more time to comply with proposed regulations that will require dramatic cuts in greenhouse-gas pollution from power plants, people familiar with the plans said Tuesday…." (Joby Warrick, Washington Post)
- CDC HEALTH ADVISORY (CDC HAN 0360 January 15, 2014): Human Infection with Avian Influenza A (H5N1) Virus
New Resources on MolecularHUB.org
- Healthmap: HealthMap, a team of researchers, epidemiologists and software developers at Boston Children's Hospital founded in 2006, is an established global leader in utilizing online informal sources for disease outbreak monitoring and real-time surveillance of emerging public health threats. The freely available Web site 'healthmap.org' and mobile app 'Outbreaks Near Me' deliver real-time intelligence on a broad range of emerging infectious diseases for a diverse audience including libraries, local health departments, governments, and international travelers. .
- dbGaP: The database of Genotypes and Phenotypes (dbGaP) was developed to archive and distribute the results of studies that have investigated the interaction of genotype and phenotype.
- Personal Genome Project UK: Personal Genome Project UK: Almost all current public data from PGP sites is from the Harvard site. As new sites grow we expect to share more data from around the world.
- Harvard PGP Data: In addition to whole genome sequencing, the Harvard PGP has a variety of donated genetic data (ranging from externally-performed genomes and exomes to direct-to-consumer genotyping).
- E-Bug: A place for children, teens, and adults to play games and learn about microbes.
- 100K Food Pathogen Project: In the Genome Project for Food Pathogens project, FDA has partnered with U.C. Davis and Agilent to map the DNA of 100,000 pathogen strains to stop foodborne illness outbreaks faster.
- Cellminer: CellMiner™ is a web application generated by the Genomics & Bioinformatics Group, LMP, CCR, NCI that facilitates systems biology through the retrieval and integration of the molecular and pharmacological data sets for the NCI-60 cell lines. The NCI-60, a panel of 60 diverse human cancer cell lines used by the Developmental Therapeutics Program of the U.S. National Cancer Institute to screen over 100,000 chemical compounds and natural products (since 1990)
- BAM files: Index of /projects/nci60/wes/BAMS/
- DTP Drug Screen: The In Vitro Cell Line Screening Project (IVCLSP) is a dedicated service providing direct support to the DTP anticancer drug discovery program.
- DTP Molecular Targets: Thousands of molecular targets have been measured in the NCI panel of 60 human tumor cell lines. Measurements include protein levels, RNA measurements, mutation status and enzyme activity levels. You can choose to search for a target of interest, or you may browse through a list of targets. Follow the links for a target to retrieve the 60 cell line data (either text or graphical), to run COMPARE (find Targets or Compounds whose patterns correlate with a Target of interest) and to link to various databases with information (function, sequences, disease associations) about the target
- Influenza Primer Design Resource: A program from Medical College of Wisconsin designed to aid researchers in translating the vast amounts of influenza sequence information into highly effective influenza diagnostics. IPDR consists of a database of all influenza nucleotide sequences and variety of bioinformatic analyses that aid in the development of primers and probes that can be used in diagnostic assays
Other Purdue News and Websites
- Oncological Sciences Center
- Indiana Clinical and Translational Sciences Institute (CTSI): accelerating clinical and translational research in healthcare
- cceHUB.org: Cancer care engineering
- CatalyzeCare.org: Transforming healthcare delivery
- The Center for Global Research and Intervention in Infectious Disease (C-GRIID)
- nanoHUB.org: A resource for nanoscience and nanotechnology, nanoHUB.org was created by the NSF-funded Network for Computational Nanotechnology
- pharmaHUB.org: pharmaHUB was created as an NSF-funded Engineering Virtual Organization with a mission to facilitate collaborative creation and sharing of information, knowledge and modeling tools that support innovations in product and process development and manufacturing methodology for pharmaceutical products
- Communities and Universities Addressing Health Disparities (CUAHD.org) : CUAHD (Communities and Universities Addressing Health Disparities) is a collaboration between Purdue University, the Indiana Minority Health Coalition (IMHC), and the African American communities in Lake and Marion Counties of Indiana working to address the disparities in heart health in the African American community